Available earliest March 1st 2019.
Contact:
Alyona Minina, PhD: alyona.minina(at)slu.se
Adrian Dauphinee, PhD: adrian.dauphinee(at)slu.se
Flyer
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| Detection of autophagy activity changes in epidermal root cells of Arabidopsis thaliana |
Autophagy is the major catabolic process of eukaryotes allowing cells to recycle their own contents. It is intensively investigated by plant biologists to elucidate mechanisms regulating plant fitness and stress tolerance. Development of precise molecular tools to study plant autophagy is a difficult but an extremely important task.
In this project we aim to study in details the effects of a drug typically used to modulate autophagy in plant cells. The project is based on strong preliminary data indicating that the effect of the drug might be much more complex than usually assumed.
Project goals:
- Quantification of successive changes in autophagy activity during the drug treatment using advanced fluorescent microscopy and biochemistry methods
- Investigating activity of potential off-targets of the drug
- Optimization of the drug concentration and treatment duration for minimizing possible side effects
You will acquire skills in:
- Advanced fluorescent microscopy
- Handling typical plant model organism Arabidopsis thaliana
- Advanced DNA and protein molecular biology methods
- Genetic engineering
Posted by Alyona Minina on the 2018.11.06.
